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Comparison of two forms of daily preventive zinc supplementation versus therapeutic zinc supplementation for diarrhea on young children’s physical growth and risk of infection: study design and rationale for a randomized controlled trial

Publication Details

Authors: K. Ryan Wessells, Kenneth H. Brown, Sengchanh Kounnavong, Maxwell A. Barffour, Guy-Marino Hinnouho, Somphou Sayasone, Charles B. Stephensen, Kethmany Rasavong, Charles R. Larson, Charles D. Arnold, Kimberly B. Harding, Gregory A. Reinhart Ganjana Lertmemongkolchai, Supan Fucharoen, Robin m. Bernstein and Sonja Y. Hess
Publication date: November 29, 2018
Source: BMC Nutrition, 4:39


The purpose of this study to compare different regimens of zinc supplementation used to for prevention of zinc deficiency and treatment of diarrhea.

A community-based, randomized controlled trial was used for this comparison. Children between 6-23 months old were divided into four intervention groups – daily preventive zinc dispersible tablet, daily preventive multiple micronutrient powder, therapeutic zinc dispersible tablet for diarrhea, or placebo control. The interventions were distributed for 9 months.

This study will provide evidence to support the best mechanisms delivering supplemental zinc.



Fortification, Lao PDR, Zinc