Cristina Palacios, Luz Maria De-Regil, Lia K. Lombardo, and Juan Pablo Peña-Rosas.

Published: February 11, 2016


The present study updates a previous meta-analysis on the effects of oral vitamin D supplementation (alone or in combination with other vitamins and minerals) during pregnancy on maternal 25(OH)D levels and risk of developing adverse gestational outcomes such as pre-eclampsia, gestational diabetes, preterm birth, impaired glucose tolerance, caesarean section, and gestational hypertension.
Fifteen randomized and quasi-randomized trials were included in the review.

Supplementing pregnant women with vitamin D led to increased levels of 25(OH)D at term compared to placebo/control but results were inconsistent. Vitamin D supplementation, with or without calcium, may be related to lower risk of preeclampsia but more studies are needed to confirm this relationship.


The Journal of Steroid Biochemistry and Molecular Biology