Luz Maria De-Regil, Cristina Palacios, Ali Ansary, Regina Kulier, and Juan Pablo Peña-Rosas.

Published: February 15, 2012


The present systematic review examines the potential of vitamin D supplementation (alone or in combination with calcium or other vitamins and minerals) to safely improve maternal and neonatal outcomes when given to women during pregnancy. The review included six trials assessing a total of 1023 women.

Authors found vitamin D supplementation in a single or continued dose during pregnancy increases serum vitamin D concentrations at term. However, the number of high quality, randomized trials and outcomes reported are too limited to draw conclusions on its usefulness and safety of this intervention as a part of routine antenatal care


Database of Systematic Reviews